Automating High-Throughput Organoid and Zebrafish Screening [WATCH NOW]

Written by
Natalie Alvarez
Feb 28, 2025
4 MIN READ min read

Transform Manual Workflows into Automated Assays

Traditional microscopy approaches remain limited by a fundamental constraint: one objective lens repeatedly scanning over multiple fields of view. This process is not only slow for large samples but makes it nearly impossible to capture dynamic changes happening in real-time across multiple wells.

Ramona has shattered this limitation with our proprietary MCAM® (Multi-Camera Array Microscope) technology, enabling researchers to image entire well plates in seconds, not hours.

Key Speaker Insights

Dr. Robyn Tanguay, Oregon State University

Using the Kestrel™ for Zebrafish Research

Dr. Tanguay's team leverages zebrafish as a powerful toxicology model to evaluate chemical bioactivity. "We purchased the Kestrel™ the day after our demo. It was that transformational for our workflow," notes Dr. Tanguay. By exposing zebrafish embryos to various chemicals, her lab identifies adverse developmental outcomes that signal potential toxicity concerns. The Kestrel™ has revolutionized their ability to capture high-quality images and extract meaningful data at unprecedented speeds. "The speed at which we're advancing segmentation with the Ramona team is remarkable," says Dr. Tanguay. "This technology is going to help us overcome the cost of labor which is reducing our discovery rates."

Key Benefits:

  • Capture an entire 96-well plate with Z-stacks in under a minute
  • Extract maximum data from living samples without compromise
  • Automatically identify and classify phenotypic changes with AI-powered analysis

Dr. Jason Stein, University of North Carolina at Chapel Hill

Scaling Organoid Research with the Vireo™

Dr. Stein's lab creates cortical organoids from iPSCs to model early fetal brain development and study genetic influences on neuropsychiatric disorders. His team uses organoids derived from individuals who previously underwent brain MRI scans, allowing them to correlate in vitro models with in vivo brain development. The Vireo™ has enabled them to dramatically scale their research from 18 to 115 participants with multiple replicates per donor. "This rapid parallelized imaging greatly reduced acquisition time, which enabled us to scale our experiments to large numbers of participants and multiple exposures," explains Dr. Stein. His lab has already demonstrated how their high-throughput model can reveal dose-dependent responses to environmental toxicants like valproic acid.

Key Benefits:

  • Reduced imaging time from 11 minutes to less than 1 minute per 96-well plate
  • Improved segmentation accuracy with Ramona's AI-powered analysis
  • Enabled studies of gene-environment interactions across multiple conditions
Webinar

Automating High-Throughput Organoid and Zebrafish Screening [WATCH NOW]

Dr. Robyn Tanguay (Oregon State University) and Dr. Jason Stein (UNC Chapel Hill) reveal how Ramona's parallel imaging technology transforms manual workflows into automated, AI-powered assays for zebrafish and organoid research.
WATCH NOW

Transform Manual Workflows into Automated Assays

Traditional microscopy approaches remain limited by a fundamental constraint: one objective lens repeatedly scanning over multiple fields of view. This process is not only slow for large samples but makes it nearly impossible to capture dynamic changes happening in real-time across multiple wells.

Ramona has shattered this limitation with our proprietary MCAM® (Multi-Camera Array Microscope) technology, enabling researchers to image entire well plates in seconds, not hours.

Key Speaker Insights

Dr. Robyn Tanguay, Oregon State University

Using the Kestrel™ for Zebrafish Research

Dr. Tanguay's team leverages zebrafish as a powerful toxicology model to evaluate chemical bioactivity. "We purchased the Kestrel™ the day after our demo. It was that transformational for our workflow," notes Dr. Tanguay. By exposing zebrafish embryos to various chemicals, her lab identifies adverse developmental outcomes that signal potential toxicity concerns. The Kestrel™ has revolutionized their ability to capture high-quality images and extract meaningful data at unprecedented speeds. "The speed at which we're advancing segmentation with the Ramona team is remarkable," says Dr. Tanguay. "This technology is going to help us overcome the cost of labor which is reducing our discovery rates."

Key Benefits:

  • Capture an entire 96-well plate with Z-stacks in under a minute
  • Extract maximum data from living samples without compromise
  • Automatically identify and classify phenotypic changes with AI-powered analysis

Dr. Jason Stein, University of North Carolina at Chapel Hill

Scaling Organoid Research with the Vireo™

Dr. Stein's lab creates cortical organoids from iPSCs to model early fetal brain development and study genetic influences on neuropsychiatric disorders. His team uses organoids derived from individuals who previously underwent brain MRI scans, allowing them to correlate in vitro models with in vivo brain development. The Vireo™ has enabled them to dramatically scale their research from 18 to 115 participants with multiple replicates per donor. "This rapid parallelized imaging greatly reduced acquisition time, which enabled us to scale our experiments to large numbers of participants and multiple exposures," explains Dr. Stein. His lab has already demonstrated how their high-throughput model can reveal dose-dependent responses to environmental toxicants like valproic acid.

Key Benefits:

  • Reduced imaging time from 11 minutes to less than 1 minute per 96-well plate
  • Improved segmentation accuracy with Ramona's AI-powered analysis
  • Enabled studies of gene-environment interactions across multiple conditions

Speakers

Dr. Robyn Tanguay
Professor, Department of Environmental & Molecular Toxicology at Oregon State University
Dr. Jason Stein
Associate Professor, Genetics & Neuroscience Center at the UNC School of Medicine

Watch now

Oops! Something went wrong while submitting the form.
Ready to transform your research?
Book a call with one of our Ramona experts:
Thanks for submitting the form,
you're officially on the list to receive updates.
Oops! Something went wrong while submitting the form.