Microscopy Reinvented
We advance breakthrough research and the visionary minds behind it.
Our Goal
High-throughput optical microscopy is transforming the science of modern biology — from genetics to drug discovery to synthetic biology. It is rapidly improving efficiency and opening up new possibilities across a wide range of applications.
But scientists today are fundamentally constrained by the limited perspective of traditional microscopes.
As field-of-view increases, resolution decreases. Yet modern biology requires an ability to capture precise data across larger areas and at multiple points in time to understand dynamic systems and reduce costs by accelerating tedious workflows.
At Ramona, we've reimagined microscopy for the modern researcher.
By equipping scientists with unprecedented speed, precision, and insight, we’re on a mission to advance human health through computational microscopy.
Resources
Recent publications and white papers, aided by Ramona technology.
Publications
- Plos One, December 2023
Automated, high-throughput quantification of EGFP-expressing neutrophils in zebrafish by machine learning and a highly-parallelized microscope
This study introduces a rapid, high-throughput approach using the Multi-Camera Array Microscope (MCAM™) to image and quantify neutrophils in zebrafish embryos—a key indicator of environmental impacts on immune function. Using advanced machine learning, the system is able to process and count individual fluorescent neutrophils across a 96-well plate in just over 5 minutes, offering a rapid and accurate alternative to traditional manual counting methods.Learn more - Nature Photonics, March 2023
Parallelized computational 3D video microscopy of freely moving organisms at multiple gigapixels per second
This article demonstrates how wide-field-of-view microscopy with Ramona’s Multi-Camera Array Microscope (MCAM™) can resolve three-dimensional information at high speed and spatial resolution. It then shows how this technology can serve as a powerful tool for studying the behavior of freely moving organisms, such as ants, fruit flies, and zebrafish larvae.Learn more - Optica, February 2023
Imaging across multiple spatial scales with the multi-camera array microscope
This publication presents results from three unique Multi-Camera Array Microscope (MCAM ™) configurations for different use cases. These configurations include simultaneous capture with 3D object depth estimation, continuous video capture at high resolution over a large field of view, and a high-resolution configuration to produce 9.8 GP composites of large histopathology specimens.Learn more - Elife, December 2022
Gigapixel imaging with a novel multi-camera array microscope
This paper details how Ramona’s Multi-Camera Array Microscope (MCAM™) enables comprehensive high-resolution recording from multiple spatial scales simultaneously, ranging from cellular-scale structures to large-group behavioral dynamics. This allows researchers to observe the behavior and fine anatomical features of numerous freely moving model organisms on multiple spatial scales, including larval zebrafish, fruit flies, nematodes, carpenter ants, and slime mold.Learn more - MDPI Agriculture, September 2022
Species Identification of Caterpillar Eggs by Machine Learning Using a Convolutional Neural Network and Massively Parallelized Microscope
This research demonstrates a machine learning technique for swift and precise insect egg identification using Ramona's Multi-Camera Array Microscope (MCAM™), distinguishing two crucial pest species with more than 99% accuracy. Validated with around 5500 images, the approach suggests new avenues for real-time agricultural pest diagnostics.Learn more - Optica, August 2021
High throughput acquisition and analysis of bacterial colony features using gigapixel microscopy
This paper details how Ramona’s Multi-Camera Array Microscope (MCAM™) can quantify morphological features in bacterial colonies across multi-well plates. It shows how the system can be used to augment high-throughput assays by synchronously capturing valuable phenotypic information throughout an acquisition and analysis pipeline.Learn more
Our Team
Based in the heart of the Research Triangle, our interdisciplinary team combines deep expertise in computer architecture, optics, computational microscopy, computer vision, machine learning, and industrial design.
Roarke Horstmeyer, PhD
Scientific Director
Mark Harfouche, PhD
Chief Technical Officer
Gregor Horstmeyer
Chief Executive Officer
Margaret Aery
Chief Operations Officer
Aurélien Bègue, PhD
Research Lead
Natalie Alvarez
Product Lead
Gail Joseph-Cabrera, PhD.
Technical Project Manager
Guillaume Smith
Microscopy Systems Technician
Veton Saliu
Embedded Systems Engineer
Jack Bechtel
Senior Applications Scientist
Clay Dugo
Senior Software Developer
John Efromson
Senior Machine Learning Engineer
Jed Doman
Senior Software Developer
Audrey Barcus
Creative Project Manager
Join Us
Help us enable discovery at the forefront of modern biology.
Ramona is seeking talented, driven, and creative individuals excited about scaling our new technology. If you’re interested in joining us, check out the job openings below, and send us your resume. We’re always looking for amazing talent, so even if a listing doesn’t seem quite right for you, we’d still love to hear from you.
How can we support your breakthrough research?Whatever your work, we’d love to learn about it and explore ways we can support your own breakthrough research.
Get in contact for a demo.
Contact us