Live imaging, meet high throughput

ORIP participates in two federal Small Business grant programs—the Small Business Innovation Research (SBIR) and the Small Business Technology Transfer (STTR)—that provide seed funding to small businesses to develop technologies that have potential for commercialization. The SBIR program is designed to encourage domestic small businesses to engage in biomedical research and development (R&D), and the STTR program is designed to facilitate cooperative R&D between small businesses and U.S. research institutions. ORIP has aligned its small business programs to develop new technologies that could benefit the research resources that the office supports, the communities that the resources support, and the research community at large. To date, this effort is enabling the support of preclinical technologies that are at several different stages of development, including diagnostic tools, drug therapies, instruments, and devices for animal facilities health monitoring and surveillance. Other ORIP-supported technologies have successfully become commercially available products in the national and international marketplace.

ORIP participates in two federal Small Business grant programs—the Small Business Innovation Research (SBIR) and the Small Business Technology Transfer (STTR)—that provide seed funding to small businesses to develop technologies that have potential for commercialization. The SBIR program is designed to encourage domestic small businesses to engage in biomedical research and development (R&D), and the STTR program is designed to facilitate cooperative R&D between small businesses and U.S. research institutions. ORIP has aligned its small business programs to develop new technologies that could benefit the research resources that the office supports, the communities that the resources support, and the research community at large. To date, this effort is enabling the support of preclinical technologies that are at several different stages of development, including diagnostic tools, drug therapies, instruments, and devices for animal facilities health monitoring and surveillance. Other ORIP-supported technologies have successfully become commercially available products in the national and international marketplace.

Biomedical researchers at Duke University have developed a computational imaging system that borrows techniques from astronomy to reconstruct 4D videos of freely moving small model organisms, like zebrafish and fruit fly larvae. By using a concave mirror and an array of sensors, researchers were able to rapidly capture the unrestrained movements of animals from dozens of synchronized viewpoints.

Biomedical researchers at Duke University have developed a computational imaging system that borrows techniques from astronomy to reconstruct 4D videos of freely moving small model organisms, like zebrafish and fruit fly larvae. By using a concave mirror and an array of sensors, researchers were able to rapidly capture the unrestrained movements of animals from dozens of synchronized viewpoints.

To study small, moving creatures such as ants or fish larvae, microscope users typically have to pick one or two items from a list of three desirables: high speed, high spatial resolution and a wide, 3D field of view. Now a new type of imaging microscope can give biologists all three properties, according to its developers.